HEALTH

Medical Breakthrough: Low-Cost Antidepressant Found to Combat Long COVID Fatigue

Researchers find that the low-cost antidepressant fluvoxamine significantly reduces fatigue in long COVID patients, offering a major breakthrough for millions.

Published

on

A Major Advance in Long COVID Treatment

A global research team co-led by McMaster University has announced a significant breakthrough in the treatment of long COVID, identifying one of the first medications proven to meaningfully reduce persistent fatigue. According to a randomized, placebo-controlled clinical trial published in the Annals of Internal Medicine, the widely available antidepressant fluvoxamine significantly improved both energy levels and the overall quality of life for patients struggling with the long-term effects of the virus.

Fatigue remains the most debilitating symptom for the estimated 65 million people living with long COVID worldwide. For many, the exhaustion is so profound that it prevents them from returning to work or engaging in daily family activities. Despite the scale of the crisis, medical guidelines have largely been limited to supportive care and pacing due to a lack of evidence-based pharmacological options.

The REVIVE-TOGETHER Trial Results

The study, known as the REVIVE-TOGETHER trial, involved 399 adults in Brazil who had experienced persistent fatigue for at least 90 days following a COVID-19 infection. Participants were randomly assigned to receive either fluvoxamine, the diabetes medication metformin, or a placebo for 60 days. The results were stark: researchers found a 99 percent probability that fluvoxamine outperformed the placebo in reducing fatigue. Conversely, while metformin has previously shown promise in preventing long COVID if taken during the initial infection, it offered no meaningful benefit for those with established fatigue symptoms.

“This is an important step forward for patients who have been desperate for evidence-based options,” said Edward Mills, senior author and professor at McMaster University. He noted that because fluvoxamine is already widely used and well-understood by the medical community, it has immediate potential for clinical application.

Innovation in Clinical Research

Beyond the discovery of the drug’s efficacy, the trial was notable for its sophisticated Bayesian adaptive design. This allowed the international team—comprising researchers from Stanford, UBC, Duke, and several Brazilian institutions—to reach conclusions more efficiently than traditional trials. The study was able to stop specific treatment arms once the evidence became clear, accelerating the delivery of much-needed data to the public.

While experts emphasize that long COVID is a complex condition that may require multiple treatment pathways, the identification of fluvoxamine provides clinicians with the first strong evidence for a medication that targets the condition’s most common symptom. Further research is expected to determine which specific patient profiles benefit most from the treatment.

Continue Reading

BC STORIES

What 5 Neurologist Resignations Mean for Regional Health Care at Interior Health

Five Interior Health neurologists have resigned following expanded regional on-call demands, adding to previous physician departures in the B.C. region.

Published

on

Five Specialists Step Down Following Regional On-Call Mandate

Five neurologists have resigned from their positions with Interior Health after being required to expand their on-call coverage across the entire health authority region via internet and telephone services. According to Doctors of B.C. president Adam Thompson, the mandate served as a tipping point after physicians expressed that the arrangement was not viable, citing concerns over workload levels.

Pattern of Physician Departures Across Regional Facilities

The decision marks another instance of staff departures within the health authority. Previous incidents include the resignation of all obstetricians and gynecologists at Kamloops’ Royal Inland Hospital last October due to workload, alongside four psychiatrists leaving Vernon Jubilee Hospital that same month. Furthermore, seven pediatricians resigned from Kelowna General Hospital between 2023 and 2025, which led to an internal report highlighting a decline in trust between physicians and administration.

Calls for Collaboration and Health Authority Response

Thompson stressed that health authority administrators must listen to and collaborate with frontline physicians to address ongoing service issues across provincial specialties. In response, Dr. Kirstie McLelland, executive medical director of clinical operations for Interior Health South, stated that election-period communication rules limited detailed comment, but affirmed that the authority remains committed to working with neurologists to meet staff rules and bylaws while delivering required care. She added that members of the public should not hesitate to seek neurology services if needed.

Continue Reading

BC STORIES

B.C. Faces an Early and Hard-Hitting Flu Season as Symptoms Intensify

B.C. flu season arrives early as Health Canada reports elevated activity. Learn about the dominant H1N1 strain, severe symptoms, and vaccine availability.

Published

on

Early Arrival and Severe Symptoms

Influenza activity in British Columbia has surged earlier than usual this year, bringing illness that health professionals describe as particularly intense. According to Health Canada data, flu test positivity across the province is running above average for this time of year, departing from the typical pattern where cases climb slowly toward a holiday peak.

Pharmacists note that the current wave is taking a heavier toll on patients compared to last year. Pharmasave pharmacist Fairuz Siraj stated, “This year it’s hitting hard. We’re seeing a lot of cases of people coming down, feeling ill, and taking more time to recover. A lot more severe type of illness than what we saw last year.”

Dominant Strain and Vaccine Alignment

Data from the Public Health Agency of Canada and the BC Centre for Disease Control show that B.C. registered a “moderate” flu activity level during the first week and a half of October, with wastewater indicators rising at multiple monitoring locations. Meanwhile, other Canadian provinces continue to report “low” or “very low” activity.

The dominant virus strain in circulation is H1N1, a form of Influenza A. On Oct. 7, B.C. Provincial Health Officer Dr. Bonnie Henry announced the launch of the provincial vaccination campaign 10 days ahead of the usual schedule. Because scientists anticipated that H1N1 would lead cases this season, the current vaccine was formulated specifically to target it. Dr. Brian Ward, a scientist at the McGill University Health Centre, noted that “so far, so good,” though he cautioned that flu viruses can mutate as the season progresses. Ward added it remains too early to know if mid-season mutations will occur and stated he is unaware of any predicted mutations that would reduce vaccine efficacy.

Vaccine Access Details

Free influenza immunizations are currently accessible to B.C. seniors and individuals in high-risk categories. Siraj advised that members of the general public seeking early protection may check walk-in clinics for availability or wait for their individual booking notification links, which are expected in late October or early November.

Continue Reading

HEALTH

Coquihalla Highway Reopens Near Merritt Following Morning Crash That Injured Four

The Coquihalla Highway north of Merritt has reopened following a Saturday morning vehicle crash that resulted in four people being taken to the hospital.

Published

on

Traffic Resumes Following Serious Morning Incident

Four people were hospitalized, including three in critical condition, after a motor vehicle incident occurred north of Merritt on Saturday morning, October 17.

DriveBC reported that the Coquihalla Highway was reopened in both directions from Exit 290 to Exit 315 at approximately 4:00 p.m., following the earlier closure.

Emergency Responders Deploy Air Ambulances

BC Emergency Health Services dispatched multiple resources after receiving a call at approximately 8:35 a.m. The response included two air ambulances, three primary care paramedic ambulances, one advanced care paramedic ambulance, and a paramedic supervisor.

According to BCEHS, crews provided emergency medical care at the scene. Two of the three critically injured patients were flown to the hospital via air ambulance, while a fourth patient was taken to the hospital in stable condition.

Continue Reading

Trending